Research and education
Clear research articles, educational guides, and considered perspectives designed to support informed laboratory review.
Research Article
An evidence-aware overview of KPV, a lysine–proline–valine tripeptide derived from α-MSH, with emphasis on proposed anti-inflammatory mechanisms, cytokine modulation, gut and epithelial effects, antimicrobial activity, and the limits of current human evidence.
Educational Guide
A practical educational guide to BPC-157 protocol design, monitoring, candidate selection, cycling, safety cautions, reconstitution concepts, and stacking ideas. It emphasizes that most support remains preclinical, human evidence is very limited, and protocol choices should be treated as cautious, individualized research-informed concepts rather than clinically proven standards.
Research Article
A gastrointestinal-focused explanation of why oral BPC-157 is discussed in relation to gut barrier physiology, tight junction proteins, intestinal permeability, inflammatory bowel disease models, NSAID-related gastrointestinal injury, alcohol-related injury, and ulcer healing. The article separates mechanistic and preclinical rationale from the current limitation: robust human clinical evidence is still lacking.
Research Article
A focused review of BPC-157’s proposed role in musculoskeletal and peripheral nerve recovery, including tendons, ligaments, muscle strains, fracture healing, and neuropathy models. The article distinguishes animal and mechanistic evidence from limited human data and explains why structural monitoring and functional outcomes matter in injury-focused use.
Research Article
An evidence-aware overview of BPC-157 as a regenerative peptide, explaining proposed mechanisms such as nitric oxide regulation, angiogenesis, cell migration, gut barrier repair, inflammatory modulation, and possible growth hormone receptor upregulation. The article emphasizes that the strongest support remains preclinical, while high-quality human clinical evidence is very limited.
Educational Guide
A reader-friendly overview of how NAD+-related approaches are framed for different goals, including general wellness, cognitive or brain fog support, athletic recovery, chronic fatigue or low energy, and clinic-based high-dose repletion. It presents protocol concepts as considerations rather than guaranteed outcomes, while noting cautions about inconsistent metabolic results and the need for supervision with intensive IV use.
Educational Guide
A safety-focused guide to NAD+ use, including common side effects, why rapid IV or larger IM administration may increase dose-rate reactions, groups that warrant extra caution, and subjective and laboratory markers that may be useful to discuss during higher-dose or longer-cycle use.
Educational Guide
A practical guide comparing common NAD+-related delivery approaches, including IV NAD+, intramuscular injections, subcutaneous injections, oral NR and NMN, and oral NADH. It explains differences in onset, tolerability, supervision needs, absorption, reported dose ranges, and the distinction between direct NAD+ administration and precursor-based NAD+ support.
Research Article
An evidence-aware explanation of NAD+ as a core coenzyme involved in electron transfer, ATP generation, DNA repair enzymes, sirtuin activity, CD38-related NAD+ degradation, inflammation regulation, and circadian rhythm signaling. It helps readers separate established cellular biology from less certain claims about fatigue, cognition, recovery, and longevity outcomes.
Educational Guide
A monitoring and safety guide for evaluating tesamorelin with objective endpoints such as IGF-1, fasting glucose, HbA1c, waist circumference, visceral fat, and liver-fat imaging when relevant. The article also explains cautious combination logic, common adverse effects, and the findings that should prompt reassessment or discontinuation.
Educational Guide
A practical guide that separates current Egrifta WR and Egrifta SV prescribing information from historical 2 mg clinical-trial dosing and off-label research conventions. The article helps readers understand why tesamorelin dosing is often confused, how timing and cycling claims should be qualified, and why branded formulations are not interchangeable.
Research Article
A research-focused review of tesamorelin evidence across visceral fat, liver fat, IGF-1, lipids, cognition, durability, and safety gaps. The strongest human evidence comes from adults with HIV-associated abdominal fat accumulation, while liver and cognition findings are narrower or earlier-stage and should not be generalized to routine weight loss, anti-aging, or cosmetic use.
Educational Guide
An accessible explanation of tesamorelin as a synthetic GHRH analog that stimulates endogenous growth hormone release rather than supplying HGH directly. The article clarifies its FDA-approved role in reducing excess abdominal fat in adults with HIV-associated lipodystrophy, distinguishes visceral-fat effects from general weight loss, and explains why broader uses require caution.
Stonehaven Perspective
Discover the full power of SS-31 in this clear, practical guide to mitochondrial optimization. From everyday longevity to high-performance recovery and advanced healing, the article breaks down three dosing tiers, reconstitution math, cycling strategies, synergistic stacks, and key biomarkers—while keeping safety and real-world expectations front and center.
Research Article
Beyond its approval for Barth Syndrome, SS-31 has been studied across kidney protection, cardiovascular function, exercise performance, neurological health, and eye disease. This piece breaks down the evidence area by area — including where results are strong (renal blood flow, exercise capacity) and where they're more mixed (human cardiovascular trials, brain penetration) — for a clear-eyed picture of what the research actually supports.
Educational Guide
SS-31 (Elamipretide) is the first FDA-approved mitochondria-targeted therapeutic, cleared as Forzinity for Barth Syndrome in 2025. Unlike peptides that work through receptor signaling, SS-31 binds cardiolipin — a key structural lipid in the mitochondria — to repair the physical architecture that energy production depends on. This piece covers its discovery, its mechanism, and why that structural approach sets it apart from compounds like BPC-157 or Semaglutide.
